Drug eruption - Erupsi Obat
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Erupsi Obat (Drug eruption) ditandai kanthi ngaruhi sakabehe awak.
relevance score : -100.0%
ReferencesReaksi kulit sing disebabake dening obat, sing dikenal minangka erupsi obat, kadhangkala bisa dadi abot. Reaksi abot iki, sing diarani severe cutaneous adverse drug reactions (SCARs), dianggep ngancam nyawa. Iki kalebu kahanan kaya Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), lan drug reaction with eosinophilia and systemic symptoms (DRESS). Nalika SCARs langka, udakara 2 % pasien rawat inap ngalami.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Wanita berusia 31 tahun mengunjungi departemen dermatologi dengan ruam merah yang tidak terasa sakit di bagian atas kaki kanan. Ia telah mengonsumsi satu dosis doxycycline (100 mg) sehari sebelumnya, setelah perawatan laser picosecond untuk bekas kukul. Tahun lalu, ia mengalami gejala yang sama di lokasi yang sama setelah menerima dosis doxycycline pasca laser yang serupa. Ia tidak memiliki riwayat medis yang signifikan dan tidak ada gejala lain, seperti gatal, baik secara lokal maupun menyebar ke seluruh tubuh.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) lan toxic epidermal necrolysis (TEN) yaiku loro wujud reaksi kulit sing serius, beda karo kondisi kulit liyane kaya erythema multiforme major lan sindrom kulit scalded staphylococcal, uga reaksi obat. SJS/TEN iku reaksi sing langka lan abot sing nyebabake karusakan kulit lan membran mukosa sing nyebar, asring disertai gejala sistemik. Ing luwih saka 80 % kasus, obat‑obatan dadi panyebab utama.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Erupsi obat didiagnosa utamane saka riwayat medis lan pemeriksaan klinis. Biopsi kulit, tes getih utawa tes imunologi uga bisa migunani.
Contoh obat umum sing nyebabake erupsi yaiku antibiotik lan obat antimikroba liyane, obat sulfa, obat anti‑inflamasi nonsteroid (NSAID), agen kemoterapi kanggo kanker, antikonvulsan, lan obat psikotropika.
○ Diagnosis lan Perawatan
Yen sampeyan duwe demam (suhu awak mundhak), sampeyan kudu njaluk bantuan medis sanalika bisa. Obat sing dicurigai kudu dihentikan (contone, antibiotik, obat anti‑inflamasi non‑steroid). Sadurunge ngunjungi rumah sakit, antihistamin oral kayata Cetirizine utawa Loratadine bisa mbantu ngurangi gatal lan ruam.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Tes getih (CBC, LFT, jumlah eosinofil)
Steroid lisan lan antihistamin kanthi resep dokter